Rumilide Plus

 

Description: Rumilide plus is an oral antibiotic blended with the power ‘of potent anti-inflammatory enzyme Serratiopeptidase. The combination of nimesulide, paracetamol & Serratiopeptidase reduces fever, inflammation and pain quickly.

Pharmacology:

Mechanism of action: Paracetamol – The main mechanism proposed is the inhibition of cyclooxygenase (COX-2). The COX family of enzymes is responsible for the metabolism of Arachidonic acid to prostaglandin H2, an unstable molecule that is, in turn, converted to numerous other pro-inflammatory compounds.

Nimesulide – It is a unique non-steroidal anti-inflammatory drug (NSAID), not only because of its chemical structure but also because of its specific affinity to inhibit cyclooxygenase-2 (COX-2), thus exerting milder effects on the gastrointestinal mucosa. It inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production. Its cyclooxygenase inhibiting potency is intermediate, but is relatively selective for the cyclo-oxygenase-2 (COX-2) thus the potential for gastric injury and intolerance is less.

Serratiopeptidase

Serratiopeptidase is an enzyme Isolated from a non-pathogenic bacteria called Enterobacteria Serratia.

It works by following mechanism of action –

  1. Fibrinolytic action Serratiopeptidase causes degradation of fibrin. Thus helps in dissolving clots.
  2. Thinning of exudates inflammatory exudates are mainly composed of foreign particles, leucocytes, erythrocytes, dead cells, etc. Serratiopeptidase helps to remove
  3. Dissolves dead tissues.
  4. Anticoagulants.

Pharmacokinetics:

Paracetomol: Well absorbed after oral administration. It is metabolised extensively in the liver to glucuronated and sulfonated forms which are then excreted via kidneys.

Nimesulide: It is well absorbed from GI tract following oral administration. Plasma protein binding is 99%. It is metabolised in liver and excreted through urine (80%) and faeces(20%) Elimination half-life is 2-5 hr.

Composition:

Nimesulide : 400 mg

Paracetamol: 1500 mg

Serratiopeptidase : 75 mg

Indications:

  • Fever
  • As a follow up after Rumilide injection.

Target Species:

Cattle, Buffalo, sheep, goat and camel.

Advantages:

  • Fast antipyretic action.
  • Reduces inflammation with quick tissue repair.
  • Safety
  • In animals, signs of acute toxicity are usually not observed unless the dosage exceeds more than 10 times. Most common are rashes, dizziness, drowsiness, diarrhea, constipation.

Dosage and administration

Large Animal – 2 Bolus BID

Small Animal – 1 Bolus BID

Presentation:

4 bolus strips

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