Description: Rumilide plus is an oral antibiotic blended with the power ‘of potent anti-inflammatory enzyme Serratiopeptidase. The combination of nimesulide, paracetamol & Serratiopeptidase reduces fever, inflammation and pain quickly.
Mechanism of action: Paracetamol – The main mechanism proposed is the inhibition of cyclooxygenase (COX-2). The COX family of enzymes is responsible for the metabolism of Arachidonic acid to prostaglandin H2, an unstable molecule that is, in turn, converted to numerous other pro-inflammatory compounds.
Nimesulide – It is a unique non-steroidal anti-inflammatory drug (NSAID), not only because of its chemical structure but also because of its specific affinity to inhibit cyclooxygenase-2 (COX-2), thus exerting milder effects on the gastrointestinal mucosa. It inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production. Its cyclooxygenase inhibiting potency is intermediate, but is relatively selective for the cyclo-oxygenase-2 (COX-2) thus the potential for gastric injury and intolerance is less.
Serratiopeptidase is an enzyme Isolated from a non-pathogenic bacteria called Enterobacteria Serratia.
It works by following mechanism of action –
- Fibrinolytic action Serratiopeptidase causes degradation of fibrin. Thus helps in dissolving clots.
- Thinning of exudates inflammatory exudates are mainly composed of foreign particles, leucocytes, erythrocytes, dead cells, etc. Serratiopeptidase helps to remove
- Dissolves dead tissues.
Paracetomol: Well absorbed after oral administration. It is metabolised extensively in the liver to glucuronated and sulfonated forms which are then excreted via kidneys.
Nimesulide: It is well absorbed from GI tract following oral administration. Plasma protein binding is 99%. It is metabolised in liver and excreted through urine (80%) and faeces(20%) Elimination half-life is 2-5 hr.
Nimesulide : 400 mg
Paracetamol: 1500 mg
Serratiopeptidase : 75 mg
- As a follow up after Rumilide injection.
Cattle, Buffalo, sheep, goat and camel.
- Fast antipyretic action.
- Reduces inflammation with quick tissue repair.
- In animals, signs of acute toxicity are usually not observed unless the dosage exceeds more than 10 times. Most common are rashes, dizziness, drowsiness, diarrhea, constipation.
Dosage and administration
Large Animal – 2 Bolus BID
Small Animal – 1 Bolus BID
4 bolus strips