Rumilide inj




Description: Rumilide is a step ahead injectable NSAID having anti-spasmodic, analgesic, anti-pyretic and anti-inflammatory actions. It alleviates pain, relieves spasms of smooth & skeletal muscles and reduces fever quickly.

Pharmacology: Mechanism of action:

Nimesulide: It is a non steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, anti-pyretic, and analgesic properties. It inhibits prostaglandin synthetase /cyclooxygenase, which limits prostaglandin production. Its cyclooxygenase inhibiting potency is intermediate, but is relatively selective for the cyclo-oxygenase-2 (COX-2) thus the potential for gastric injury and intolerance is less. It is also a free radical scavenger, and helps protect against the tissue damage that occurs during inflammation.

Pitofenone & Fenpiverinium: ACh is released from the nerve into the synaptic cleft and binds to ACh receptors on the post-synaptic membrane, relaying the signal from the nerve. ACh E, also located on the post-synaptic membrane, terminates the signal transmission by hydrolyzing ACh. The liberated choline is taken up again by the pre-synaptic nerve and ACh is synthesized by combining with acetyl-CoA through the action of choline acetyl transferase: For a cholinergic neuron to receive another impulse, ACh must be released from the ACh receptor. This occurs only when the concentration of ACh in the synaptic cleft is very low. Inhibition of ACh E leads to accumulation of ACh in the synaptic cleft and results in impeded neurotransmission.


Nimesulide – Nimesulide undergoes extensive biotransformation, mainly to 4- hydroxyl Nimesulide (which also appears to be biologically active). Nimesulide has a relatively rapid onset of action, with meaningful reductions in pain and inflammation observed within 15 minutes from drug intake. The therapeutic effects of Nimesulide are the result of its complete mode of action which targets a number of key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.

Pitofenone & Fenpiverinium- good absorption after intramuscular injection and faster action.


Each ml contains:

Nimesulide: 100 mg

Pitofenone: 2 mg

Fenpiverinium: 0.02 mg


  • Musculoskeletal pain, Post-operative pain, Lameness and arthritis abdominal pain.
  • Fever

Targeted Species: For Cattle, Buffalo, Sheep and Goat, Camel.


  • Effective in all types of pain and fever Quick action
  • Longer duration of effect
  • Special Precaution
  • Nimesulide is contraindicated in patients suffering from active peptic ulcer, moderate to severe hepatic impairment and severe renal failure. Nimesulide should be used with great caution in patients with compromised renal function, liver cirrhosis, congestive heart failure, renovascular disease.

Dosage and administration:

Cattle & buffalo – 4m1/100kg b. wt. by I/M route only.

Sheep & Goat -1ml/20kg b. wt. by I/M route only.


30 ml & 100 ml vial.

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