Mofoi


 

 

Description: Mofoi containing Moxifloxacin which is advanced 4th generation fluroquinolone having widest spectrum activity against Bacteria, Mycoplasma, Chlamydia, Fungus and others.

Pharmacology:

Mode of Action:

  • The bactericidal action of moxifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV.
  • DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA.
  • Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.

Pharmacokinetics:

After IM/IV injection, moxifloxacin is absorbed well. Its bioavailability approaches ninety per cent. Moxifloxacin has wide tissue distribution. Plasma protein binding is approximately 40 to 50%. The t1/2 is about twelve hours. It undergoes conjugation with glucuronide and sulfate and then it is eliminated mainly through the kidney and faeces. In animal studies it has been found to be secreted during lactation.

Composition:

Each ml contains:

Moxifloxacin hydrochloride B.P.

which is equivalent to 100 mg moxifloxacin.

Indications:

  • Respiratory Infections: Pneumonia, Bronchopneumonia, Bovine Respiratory Diseases (BRD), Haemorrhagic septicaemia (HS), Chronic Bovine Pleuro Pneumonia (CBPP)
  • Mammary Infections: Mastitis
  • Uterine Infections: Metritis, Endometritis, Pyometra, ROP

Target Species: Cattle, buffalo, sheep, goat

Advantages:

  1. Broad spectrum
    1. Active against gram positive and negative bacteria
    2. Active against Mycoplasma and Chlamydia
    3. Active against Fungus
  2. Long acting
    1. Maintain effective MIC level for 24 hrs
  3. Almost 90% bio-availability
  4. Faster onset of action

Contra-indications: Do not use in Hypersensitivity to moxifloxacin.

Dosage and Route:

As directed by the Veterinarian.

The recommended dosage rate is 5 mg/kg body weight (1ml per 20kg body weight) by IM/IV route.

Withdrawal Period:

Milk for human consumption: Milk taken from animal should not be used for human consumption during treatment or for 7 days after treatment.

Meat for human consumption: Animals must not be slaughtered for human consumption during treatment. Animals may be slaughtered for human consumption only after 28 days from last treatment.

Storage:

  • Store at room temperature
  • Protect from light.

Pack Size:

25 ml

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