Durocin is an oral antibiotic solution containing Enrofloxacin and Bromhexine HCl in Double strength which can be used for treatment of a number of bacterial infections affecting Respiratory, GI tract, Urinary, Skin and Soft tissue infections etc.
Mode of Action/ Pharmacology:
- Enrofloxacin is a 2nd generation fluroquinolone works by inhibiting the process of DNA synthesis within the bacterial cells, which results in cell death.
- This drug is commonly used to treat a range of bacterial infections, including those of the skin, urinary tract and respiratory system, as well as infections that result from wounds.
- Bromhexine is an oral mucolytic agent. Bromhexine acts on the mucus at the formative stages in the glands, within the mucus-secreting cells.
- Bromhexine disrupts the structure of acid mucopolysaccharide fibres in mucoid sputum and produces a less viscous mucus, which is easier to expectorate.
- After oral dose, blood concentrations usually peak within 1-3 hours.
- It penetrates all tissues well & quickly. Particularly higher concentrations are found in kidney, liver & bile. Most of them cross placental barrier.
- Enrofloxacin is mainly diethylated to its metabolite Ciprofloxacin which is also an active fluroquinolone widely used in human medications.
- Conjugation with glucuronic acid then ensues, followed by excretion which is maily through renal.
- Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver. Its oral bioavailability is stated to be only about 20%.
- It is widely distributed to body tissues and is highly bound to plasma proteins. About 85 to 90% of a dose is excreted in the urine mainly as metabolites. It has a terminal elimination half-life of up to about 12 hours. Bromhexine crosses the blood brain barrier and small amounts cross the placenta.
Each ml contains:
Enrofloxacin: 200 mg
Bromhexine: 15 mg
- Respiratory Tract Infection
Bronchitis, Pneumonia, Bronchopneumonia, Purulent nasal discharge
- GI Tract Infection
Enteritis , Diarrhoea
- Urinary Tract Infection
- Skin & Soft Tissue Infection
- Mixed Bacterial & Mycoplasmal Infections
Cattle, Buffalo, Sheep & Goat
- Animals with hypersensitivity to fluroquinolones and renal impairement should be avoided to this preparation as elimination of enrofloxacin and Bromhexine is mainly through renal excretion.
1 ml per 20 kg body weight for 3-5 days or as directed by the Veterinarian
- Milk: 2-3 days
- Meat: 8 Days
To be stored in room temperature. Away from direct sunlight.
100 ml and 500 ml bottle