Durocin DS

 

 

 

Description:

Durocin is an oral antibiotic solution containing Enrofloxacin and Bromhexine HCl in Double strength which can be used for treatment of a number of bacterial infections affecting Respiratory, GI tract, Urinary, Skin and Soft tissue infections etc.

Mode of Action/ Pharmacology:

Enrofloxacin:

  • Enrofloxacin is a 2nd generation fluroquinolone works by inhibiting the process of DNA synthesis within the bacterial cells, which results in cell death.
  • This drug is commonly used to treat a range of bacterial infections, including those of the skin, urinary tract and respiratory system, as well as infections that result from wounds.

Bromhexine:

  • Bromhexine is an oral mucolytic agent. Bromhexine acts on the mucus at the formative stages in the glands, within the mucus-secreting cells.
  • Bromhexine disrupts the structure of acid mucopolysaccharide fibres in mucoid sputum and produces a less viscous mucus, which is easier to expectorate.

Pharmacokinetics:

Enrofloxacin:

  • After oral dose, blood concentrations usually peak within 1-3 hours.
  • It penetrates all tissues well & quickly. Particularly higher concentrations are found in kidney, liver & bile. Most of them cross placental barrier.
  • Enrofloxacin is mainly diethylated to its metabolite Ciprofloxacin which is also an active fluroquinolone widely used in human medications.
  • Conjugation with glucuronic acid then ensues, followed by excretion which is maily through renal.

Bromhexine:

  • Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver. Its oral bioavailability is stated to be only about 20%.
  • It is widely distributed to body tissues and is highly bound to plasma proteins. About 85 to 90% of a dose is excreted in the urine mainly as metabolites. It has a terminal elimination half-life of up to about 12 hours. Bromhexine crosses the blood brain barrier and small amounts cross the placenta.

Composition:

Each ml contains:

Enrofloxacin: 200 mg

Bromhexine: 15 mg

Indications:

  1. Respiratory Tract Infection

Bronchitis, Pneumonia, Bronchopneumonia, Purulent nasal discharge

  1. GI Tract Infection

Enteritis , Diarrhoea

  1. Urinary Tract Infection
  2. Skin & Soft Tissue Infection
  3. Mixed Bacterial & Mycoplasmal Infections

Targeted Species:

Cattle, Buffalo, Sheep & Goat

Specific Precaution:

  • Animals with hypersensitivity to fluroquinolones and renal impairement should be avoided to this preparation as elimination of enrofloxacin and Bromhexine is mainly through renal excretion.

Dosage:

1 ml per 20 kg body weight for 3-5 days or as directed by the Veterinarian

Withdrawal Period:

  • Milk: 2-3 days
  • Meat: 8 Days

Storage:

To be stored in room temperature. Away from direct sunlight.

Presentation:

100 ml and 500 ml bottle

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