Description: BovixinTM LA is a ready-to-use, broad-spectrum and long-acting injectable antibiotic solution registered for use in cattle, buffalo, sheep, goat and pig.
Mode of Action
- Tetracyclines enter microorganisms partially by passive diffusion, partly by energy-dependant active transport. Susceptible cells concentrate the drug.
- With the cell, tetracyclines bind reversibly to receptors on the 30S ribosomal subunit, blocking the binding of aminoacyl-tRNA to the acceptor site on the mRNA-ribosome complex and thus effectively preventing addition of new amino acids to the peptide chain, therefore inhibiting protein synthesis.
- Tetracyclines are also believed to bid reversibly to 50S subunit of ribosomes and additionally alter cytoplasmic membrane permeability in susceptible organisms.
- In high concentration, tetracyclines can inhibit protein synthesis in mammalian cells.
Following intramuscular injection, peak levels in 30 minutes to several hours, depending on site and volume of injection.
- Wide distribution in tissues and body fluids. Distributed to heart, kidney, lungs, muscle, pleural fluid, bronchial secretions, sputum, bile, saliva, urine, synovial fluid, ascitic fluid, ocular aqueous humour and vitreous humour.
- Only low concentrations in CSF.
- Cross the placenta.
- Distributed into milk.
- Deposited in developing teeth; following direct dosing or dosing of the mother in late pregnancy, may result in discoloured teeth and enamel defects in the temporary teeth.
Plasma Protein binding / Storage:
Oxytetracycline plasma protein-binding is about 10-40%.
- Mainly eliminated in bile and urine.
- Ten times higher concentration in bile than in serum, partial re-absorption (enterohepatic circulation).
- 10-50% of tetracyclines are excreted, primarily by glomerular filtration, in urine.
- 10-40% excreted in faeces.
- Elimination half-life may be prolonged in individuals with renal impairment, leading to drug accumulation with repeated dosing.
Each ml contains: Oxytetracycline Dihydrate I.P. Equivalent to anhydrous Oxytetracycline 200 mg 2- pyrrolidone vehicle system QS.
- Active against many Gram positive and Gram negative bacteria (including some anaerobes)
- Active against the Gram-positive organisms: Actinomyces, Bacillus anthracis, Clostridium perfringens, Clostridium tetany, Listeria monocytogenes, Nocardia spp.
- Active against some strains of staphylococci (Staphylococcus) and streptococci (streptococcus spp.)
- Active against the Gram-negative bacteria: Bordetella, Brucella spp., Bartonella spp., Haemophilus spp., Pasteurella multocida, Shigella, Yersinia pestis.
- Little useful activity against Escheria coli, Salmonella, Proteus spp., Pseudomonas spp.
- Active against rickettsiae, chlamydiae (Chlamydia), mycoplasma (Mycoplasma spp.), L-forms.
- Active against spirochetes.
- Active against some protozoa (Proctista) such as amoebas, Anaplasma, Coccidia.
Treatment of infections due to micro-organisms sensitive to Oxytetracycline in tissues where the distribution of the antibiotic in the infectious site is in effective concentration, within the limits of its pharmacokinetic characteristics.
Generally BovixinTM LA is recommended where ever prolonged antibiotic therapy or prophylactic activity is expected and where, for practical, economic or veterinary reasons, frequent animal handling and repeat dosing is not feasible.
BovixinTM LA indicated for use in cattle, buffalo, sheep, goat and pigs in the treatment of:
- Bacterial: Metritis, Endometritis, Pyometra, HS, BQ, Mastitis, Anthrax, Diphtheria, Pneumonia, Calf scour, Enteritis, Joint ill, Naval ill, CCPP, Leptospirosis, Three day sickness/ Ephemeral fever, Wooden tongue, Foot rot, Wounds & Surgical conditions, Secondary bacterial infections.
- Protozoal: Amebiasis, Anaplasmosis and Coccidiosis.
Target Species: Cattle, buffalo, sheep, goat and pig
- Broad spectrum
- Active against gram positive and negative bacteria
- Active against some protozoa
- Active against Rickettsia, Chlamydia
- Long acting
- Maintain effective MIC level for more >72 hrs
- Tissue concentration
- Higher tissue concentration at the site of infection
- High bio-availability
- Higher drug that reaches the systemic circulation or site of infection.
- Low protein binding
- Higher drug available for antimicrobial activity
- Cost effective
- Do not use in cats, dogs and horses.
- Do not use in Liver or renal failure.
- Do not use in Hypersensitivity to Tetracyclines.
- The use of tetracyclines during the period of tooth and bone development, including late pregnancy, may lead to discolouration.
- Do not administer BovixinTM LA to piglets on the same day that they are injected with iron.
- Do not mix with intravenous calcium preparations.
- Use only in Cattle, Buffalo, Sheep, Goat and Pig.
Dosage and Route:
As directed by the Veterinarian.
The recommended dosage rate is 20 mg/kg body weight (1ml per 10kg body weight) by deep intramuscular injection.
In case of severe infections the injection can be repeated after 72 hours.
Milk for human consumption: Milk taken from animal should not be used for human consumption during treatment or for 7 days after treatment.
Meat for human consumption: Animals must not be slaughtered for human consumption during treatment. Animals may be slaughtered for human consumption only after 21 days from last treatment.
- Store in dry place below 30C.
- Protect from light.
- Do not freeze.
30 ml and 50 ml