Description: Bendofen is combination of Fenbendazole and Ivermectin. Both anthelmintic acts synergistically ensuring complete protection against all stages of roundworm and tapeworm infestation in bovines.
Pharmacology: Mechanism of action:
Fenbendazole: It selectively inhibits tubulin polymerization of parasites which leads to degeneration of parasitic microtubule. Consequently there is inhibition of cellular transport and energy metabolism. Parasite dies due to lack of energy and inhibition of waste product excretion. The most important factor in its efficacy is prolongation of contact time between drug and parasite. Also, the drug inhibits fumerate reductase mechanism which is essential component of fermentation (the process by which many parasites obtain their source of energy).
Ivermectin: It potentiates glutamate-gated chloride channels in parasite. It stimulates more GABA release which increases normal resting potential of post synaptic cells. Due to this neurotransmitters are blocked. Paralysis and death occur due to increased permeability to chloride ions and hyperpolarization of nerve cells.
Fenbendazole is sparingly soluble in water so its absorption is low. It gets absorbed within 6-30 hrs from gastrointestinal tract. After oral dosing in calves, a peak blood level of 0.11 microgram/ml was measured. Benzimidazoles and their metabolites re-enter the GI tract by passive diffusion, but the biliary route is the most important pathway for secretion and recycling of benzimidazoles. In ruminants, the benzimidazoles are most effective if deposited directly into the rumen. It is excreted unchanged in the faeces, and <1% in the urine.
Ivermectin is well distributed to most tissues, but does not readily penetrate into the CSF, thereby minimizing its toxicity. Ivermectin has a long terminal half-life in most species. It is
metabolized in the liver via oxidative pathways and is primarily excreted in the faeces. Less than 5% of the drug (as parent compound or metabolites) is excreted in the urine.
Each bolus of contains:
Fenbendazole: 3000 mg
Ivermectin: 100 mg
Fenbendazole is a broad spectrum benzimidazole anthelmintic. The drug is very active against the major ruminant parasites of the abomasum, small intestine, large intestine and lungs. Fenbendazole is effective against roundworms, hookworms, whipworms and certain tapeworms. It is effective against immature and arrested larvae and adult nematodes. Ivermectin is also a broad-spectrum anthelmintic effective against gasto intestinal nematodes and ectoparasites (Lice and mites).
Targeted Species: For Cattle, Buffalo, sheep, goat and cattle.
- Broad spectrum efficacy against roundworms and tapeworms Effective against all stages of worms
- Safe for all age group of animals
- Non teratogenic
- Safe during pregnancy
- Fenbendazole is apparently well tolerated at doses up to 100 times of recommended dose Fenbendazole and Ivermectin are safe in pregnant animals.
- Fenbendazole and Ivermectin can be given to animal of any age above 4 week
Dosage and Administration: One bolus for 300-350 kg b. wt.
Presentation: Single bolus strip