Description: Bactogon contains third generation cephalosporin Ceftriaxone.

Pharmacology: Ceftriaxone is a third-generation semi synthetic bactericidal cephalosporin, resistant to various types of bacterial 13-lactamases. It is effective against a wide variety of Gram-positive and Gram-negative bacteria It has rapid absorption and wide distribution in tissues as well as body fluids, with good tolerance after parental administration in animals.

Mechanism of action:

Ceftriaxone works by inhibiting synthesis of the bacterial cell wall. The beta-lactam functional group of Ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell wall synthesis and cell division. By binding to these enzymes, Ceftriaxone results in the formation of defective cell walls and cell death.


Ceftriaxone can be administered intravenously and intramuscularly. Protein-binding ranges from 58-96%. It is distributed into most body tissues including gallbladder, liver, kidney, bone, uterus, ovary, sputum, and fluids including urine, biliary, peritoneal, pleural, middle ear and synovial fluids. Ceftriaxone penetrates inflamed meninges and reaches therapeutic levels within the CSF. The drug can also cross placenta. Approximately 33-67% of Ceftriaxone is excreted into the urine and through faeces via bile. Following biliary excretion, a small amount of the drug is metabolized in the intestines to an inactive metabolite prior to faecal excretion. In patients with normal renal function, the elimination half-life is 6 to 9 hours.


Ceftriaxone sodium: 3000 mg/ 4000 mg


  • Pneumonia
  • Bronchopneumonia
  • Hemorrhagic Septicaemia
  • Metritis
  • Endometritis
  • Pyometra
  • Mastitis

Targeted Species: Cattle, buffalo, sheep, goat and camel


  • Bactericidal
  • Effective against Gram+ve and Gram-ve bacteria. (Aerobes and Anaerobes) Safe in pregnancy


No teratogenic effects were demonstrated in studies in pregnant mice and rats given up to 20 times labelled doses of Ceftriaxone.

Special Precautions:

Special precaution should be taken while administration in animals with history of penicillin allergy, severe renal problem, super infection.

Drug Interactions:

Should not be administered with parenteral aminoglycosides.

Do not mix with calcium or administer calcium-containing solutions or products within 48 hours of Ceftriaxone administration.

Dosage and Administration: 5-10 mg/kg b.wt. by I/M or IV routes for 3-5 days

Presentation: Ceftriaxone sodium- 3g/4g/5g vials with WFI, antiseptic swab, syringe and needle.

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